The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus pessimistic prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be signifi cantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative diseases are pathologies of multifactorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most eff ective neuroprotective strategies and individualised treatment before manifest pathology. Utilisation of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organisation, United Nations and the European Union among others. Extensive eff orts of international consortia are essential in the fi eld to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, eff ective prevention in groups at high risk and targeted treatments. This book volume “Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future” is intended to serve as a reference source for basic researchers and healthcare industry involved in the fi eld of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.